Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

The M2-1 protein of human metapneumovirus (HMPV) is a zinc-binding transcription antiterminator which is highly conserved among pneumoviruses. We report the structure of tetrameric HMPV M2-1. Each protomer features a N-terminal zinc finger domain and an α-helical tetramerization motif forming a rigi...

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Bibliographic Details
Main Authors: Cedric Leyrat, Max Renner, Karl Harlos, Juha T Huiskonen, Jonathan M Grimes
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
human metapneumovirus
virus transcription
RNA polymerase
structural virology
Online Access:https://elifesciences.org/articles/02674

Internet

https://elifesciences.org/articles/02674

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