2-Methoxyestradiol TPGS Micelles Attenuate Cyclosporine A-Induced Nephrotoxicity in Rats through Inhibition of TGF-β1 and p-ERK1/2 Axis

2-Methoxyestradiol TPGS Micelles Attenuate Cyclosporine A-Induced Nephrotoxicity in Rats through Inhibition of TGF-β1 and p-ERK1/2 Axis

The immunosuppressant cyclosporine A (CSA) has been linked to serious renal toxic effects. Although 2-methoxyestradiol (2ME) possesses a wide range of pharmacological abilities, it suffers poor bioavailability after oral administration. The purpose of this study was to evaluate the potential of 2ME...

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Bibliographic Details
Main Authors: Mohammed W. Al-Rabia, Mohamed A. Alfaleh, Hani Z. Asfour, Waleed S. Alharbi, Mohamed A. El-Moselhy, Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Omar Fahmy, Omar M. Rashad, Abdulmohsin J. Alamoudi, Ashraf B. Abdel-Naim
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
cyclosporine A
2-methoxyestradiol
TPGS
nephrotoxicity
TGF-β1
p-ERK
Online Access:https://www.mdpi.com/2076-3921/11/8/1499

Internet

https://www.mdpi.com/2076-3921/11/8/1499

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