Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

Abstract Background Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. Methods Single-cell RNA sequencing was performed including 5...

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Main Authors: Yu-bin He, Hai-zhen Jin, Jin-long Zhao, Chong Wang, Wen-rui Ma, Jie Xing, Xiao-bin Zhang, Yang-yang Zhang, Huang-dong Dai, Nai-shi Zhao, Jian-feng Zhang, Guan-xin Zhang, Jing Zhang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Medicine
Subjects:
Single-cell RNA sequencing
Acute thoracic aortic dissection
Cell differentiation trajectory
CXCL12
Cell–cell interaction
Phenotypic switch
Online Access:https://doi.org/10.1186/s10020-022-00584-4

Internet

https://doi.org/10.1186/s10020-022-00584-4

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