The effects of antibiotic cycling and mixing on acquisition of antibiotic resistant bacteria in the ICU: A post-hoc individual patient analysis of a prospective cluster-randomized crossover study.

The effects of antibiotic cycling and mixing on acquisition of antibiotic resistant bacteria in the ICU: A post-hoc individual patient analysis of a prospective cluster-randomized crossover study.

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<h4>Background</h4>Repeated rotation of empiric antibiotic treatment strategies is hypothesized to reduce antibiotic resistance. Clinical rotation studies failed to change unit-wide prevalence of antibiotic resistant bacteria (ARB) carriage, including an international cluster-randomized...

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Bibliographic Details
Main Authors: Pleun J van Duijn, Walter Verbrugghe, Philippe G Jorens, Fabian Spöhr, Dirk Schedler, Maria Deja, Andreas Rothbart, Djillali Annane, Christine Lawrence, Matjaz Jereb, Katja Seme, Franc Šifrer, Viktorija Tomič, Francisco Estevez, Jandira Carneiro, Stephan Harbarth, Marc J M Bonten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0265720

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https://doi.org/10.1371/journal.pone.0265720

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