A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

Metazoan proteomes contain many paralogous proteins that have evolved distinct functions. The Ena/VASP family of actin regulators consists of three members that share an EVH1 interaction domain with a 100 % conserved binding site. A proteome-wide screen revealed photoreceptor cilium actin regulator...

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Bibliographic Details
Main Authors: Theresa Hwang, Sara S Parker, Samantha M Hill, Meucci W Ilunga, Robert A Grant, Ghassan Mouneimne, Amy E Keating
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
protein-protein interaction
short linear motif
epistasis
actin
Ena/VASP
protein specificity
Online Access:https://elifesciences.org/articles/70601

Internet

https://elifesciences.org/articles/70601

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