Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia
Humans elicit a robust series of physiological responses to maintain adequate oxygen delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O2) affinity. However, high Hb-O2 affinity has been identified as a beneficial adaptation in several species that have been exposed t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.763933/full |
| _version_ | 1818940514589736960 |
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| author | Kevin L. Webb Paolo B. Dominelli Sarah E. Baker Stephen A. Klassen Stephen A. Klassen Michael J. Joyner Jonathon W. Senefeld Chad C. Wiggins |
| author_facet | Kevin L. Webb Paolo B. Dominelli Sarah E. Baker Stephen A. Klassen Stephen A. Klassen Michael J. Joyner Jonathon W. Senefeld Chad C. Wiggins |
| author_sort | Kevin L. Webb |
| collection | DOAJ |
| description | Humans elicit a robust series of physiological responses to maintain adequate oxygen delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O2) affinity. However, high Hb-O2 affinity has been identified as a beneficial adaptation in several species that have been exposed to high altitude for generations. The observed differences in Hb-O2 affinity between humans and species adapted to high altitude pose a central question: is higher or lower Hb-O2 affinity in humans more advantageous when O2 availability is limited? Humans with genetic mutations in hemoglobin structure resulting in high Hb-O2 affinity have shown attenuated cardiorespiratory adjustments during hypoxia both at rest and during exercise, providing unique insight into this central question. Therefore, the purpose of this review is to examine the influence of high Hb-O2 affinity during hypoxia through comparison of cardiovascular and respiratory adjustments elicited by humans with high Hb-O2 affinity compared to those with normal Hb-O2 affinity. |
| first_indexed | 2024-12-20T06:40:51Z |
| format | Article |
| id | doaj.art-85b238d6714e41828a3de30fc5f0dd0a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T06:40:51Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-85b238d6714e41828a3de30fc5f0dd0a2022-12-21T19:49:52ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-01-011210.3389/fphys.2021.763933763933Influence of High Hemoglobin-Oxygen Affinity on Humans During HypoxiaKevin L. Webb0Paolo B. Dominelli1Sarah E. Baker2Stephen A. Klassen3Stephen A. Klassen4Michael J. Joyner5Jonathon W. Senefeld6Chad C. Wiggins7Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United StatesDepartment of Kinesiology, University of Waterloo, Waterloo, ON, CanadaDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United StatesDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United StatesDepartment of Kinesiology, Brock University, St. Catharines, ON, CanadaDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United StatesDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United StatesDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United StatesHumans elicit a robust series of physiological responses to maintain adequate oxygen delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O2) affinity. However, high Hb-O2 affinity has been identified as a beneficial adaptation in several species that have been exposed to high altitude for generations. The observed differences in Hb-O2 affinity between humans and species adapted to high altitude pose a central question: is higher or lower Hb-O2 affinity in humans more advantageous when O2 availability is limited? Humans with genetic mutations in hemoglobin structure resulting in high Hb-O2 affinity have shown attenuated cardiorespiratory adjustments during hypoxia both at rest and during exercise, providing unique insight into this central question. Therefore, the purpose of this review is to examine the influence of high Hb-O2 affinity during hypoxia through comparison of cardiovascular and respiratory adjustments elicited by humans with high Hb-O2 affinity compared to those with normal Hb-O2 affinity.https://www.frontiersin.org/articles/10.3389/fphys.2021.763933/fullaltitude acclimatizationhigh-altitudeoxygen transportexerciseVO2max (maximal oxygen uptake)high affinity hemoglobin (Hb) |
| spellingShingle | Kevin L. Webb Paolo B. Dominelli Sarah E. Baker Stephen A. Klassen Stephen A. Klassen Michael J. Joyner Jonathon W. Senefeld Chad C. Wiggins Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia Frontiers in Physiology altitude acclimatization high-altitude oxygen transport exercise VO2max (maximal oxygen uptake) high affinity hemoglobin (Hb) |
| title | Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia |
| title_full | Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia |
| title_fullStr | Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia |
| title_full_unstemmed | Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia |
| title_short | Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia |
| title_sort | influence of high hemoglobin oxygen affinity on humans during hypoxia |
| topic | altitude acclimatization high-altitude oxygen transport exercise VO2max (maximal oxygen uptake) high affinity hemoglobin (Hb) |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.763933/full |
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