Personalized mechanical ventilation guided by ultrasound in patients with acute respiratory distress syndrome (PEGASUS): study protocol for an international randomized clinical trial

Personalized mechanical ventilation guided by ultrasound in patients with acute respiratory distress syndrome (PEGASUS): study protocol for an international randomized clinical trial

Abstract Background Acute respiratory distress syndrome (ARDS) is a frequent cause of hypoxemic respiratory failure with a mortality rate of approximately 30%. Identifying ARDS subphenotypes based on “focal” or “non-focal” lung morphology has the potential to better target mechanical ventilation str...

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Bibliographic Details
Main Authors: Jante S. Sinnige, Marry R. Smit, Aniruddha Ghose, Harm-Jan de Grooth, Theis Skovsgaard Itenov, Eleni Ischaki, John Laffey, Frederique Paulus, Pedro Póvoa, Charalampos Pierrakos, Luigi Pisani, Oriol Roca, Marcus J. Schultz, Konstanty Szuldrzynski, Pieter R. Tuinman, Claudio Zimatore, Lieuwe D. J. Bos, for the PEGASUS investigators
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Trials
Subjects:
Acute respiratory distress syndrome
Personalized medicine
Mechanical ventilation
Lung ultrasound
Online Access:https://doi.org/10.1186/s13063-024-08140-7

Internet

https://doi.org/10.1186/s13063-024-08140-7

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