Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth

Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth

<p>Abstract</p> <p>Background</p> <p>Constitutive activation of Ras in immortalized bronchial epithelial cells increases electron transport chain activity, oxygen consumption and tricarboxylic acid cycling through unknown mechanisms. We hypothesized that members of the...

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Bibliographic Details
Main Authors: Telang Sucheta, Nelson Kristin K, Siow Deanna L, Yalcin Abdullah, Thornburg Joshua M, Imbert-Fernandez Yoannis, Klarer Alden C, Farghaly Hanan, Clem Brian F, Eaton John W, Chesney Jason
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Molecular Cancer
Subjects:
Mitochondria
Glycolysis
Tricarboxylic acid cycle
Electron transport chain
Oncogene
Online Access:http://www.molecular-cancer.com/content/11/1/60

Internet

http://www.molecular-cancer.com/content/11/1/60

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