Modelling Takenouchi-Kosaki syndrome using disease-specific iPSCs

Modelling Takenouchi-Kosaki syndrome using disease-specific iPSCs

Takenouchi-Kosaki Syndrome (TKS) is a congenital multi-organ disorder caused by the de novo missense mutation c.191A > G p. Tyr64Cys (Y64C) in the CDC42 gene. We previously elucidated the functional abnormalities and thrombopoietic effects of Y64C using HEK293 and MEG01 cells. In the present stud...

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Bibliographic Details
Main Authors: Suganya Thanasegaran, Etsuko Daimon, Yukinao Shibukawa, Natsuko Yamazaki, Nobuhiko Okamoto
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Stem Cell Research
Subjects:
TKS
iPSC
Disease model
Platelet disorder
Stem cell differentiation
Megakaryopoiesis
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506123002076

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http://www.sciencedirect.com/science/article/pii/S1873506123002076

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