Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials.

Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials.

Acanthamoeba is normally free-living, but sometimes facultative and occasionally opportunistic parasites. Current therapies are, by necessity, arduous and yet poorly effective due to their inabilities to kill cyst stages or in some cases to actually induce encystation. Acanthamoeba can therefore sur...

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Bibliographic Details
Main Authors: Christopher A Rice, Sara J Campbell, Claudine Bisson, Hayley J Owen, Svetlana E Sedelnikova, Patrick J Baker, David W Rice, Fiona L Henriquez, Craig W Roberts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6029752?pdf=render

Internet

http://europepmc.org/articles/PMC6029752?pdf=render

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