Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

Background: Propylthiouracil (PTU) treats hyperthyroidism and thyroid crisis in all age groups. A variety of serious adverse effects can occur during clinical use and require attention to its pharmacokinetic and pharmacodynamic characteristics in various populations.Objective: To provide information...

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Bibliographic Details
Main Authors: Chaozhuang Shen, Dahu Liang, Xiaohu Wang, Wenxin Shao, Kuo Geng, Xingwen Wang, Hua Sun, Haitang Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
propylthiouracil (PTU)
PBPK
PK-sim®
extrapolation
elderly
pediatric
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1013432/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1013432/full

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