Anti-high-mobility group box-1 (HMGB1) mediates the apoptosis of alveolar epithelial cells (AEC) by receptor of advanced glycation end-products (RAGE)/c-Jun N-terminal kinase (JNK) pathway in the rats of crush injuries

Anti-high-mobility group box-1 (HMGB1) mediates the apoptosis of alveolar epithelial cells (AEC) by receptor of advanced glycation end-products (RAGE)/c-Jun N-terminal kinase (JNK) pathway in the rats of crush injuries

Abstract Objectives The lung injury is often secondary to severe trauma. In the model of crush syndrome, there may be secondary lung injury. We hypothesize that high-mobility group box 1 (HMGB1), released from muscle tissue, mediates the apoptosis of alveolar epithelial cells (AEC) via HMGB1/Recepto...

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Bibliographic Details
Main Authors: Bin-Fei Zhang, Wei Song, Jun Wang, Peng-Fei Wen, Yu-Min Zhang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Crush injury
High-mobility group box-1
Receptor of advanced glycation end-products (RAGE)
c-Jun N-terminal kinase (JNK)
SP600125
Apoptosis
Online Access:https://doi.org/10.1186/s13018-021-02903-7

Internet

https://doi.org/10.1186/s13018-021-02903-7

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