HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying molecular interactions that drive aging remain enigmatic. Here, we develop quantitative time-resolved crosslinking mass spectrometry to monitor prote...
Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/69377 |