HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying molecular interactions that drive aging remain enigmatic. Here, we develop quantitative time-resolved crosslinking mass spectrometry to monitor prote...

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Bibliographic Details
Main Authors: Edgar E Boczek, Julius Fürsch, Marie Laura Niedermeier, Louise Jawerth, Marcus Jahnel, Martine Ruer-Gruß, Kai-Michael Kammer, Peter Heid, Laura Mediani, Jie Wang, Xiao Yan, Andrej Pozniakovski, Ina Poser, Daniel Mateju, Lars Hubatsch, Serena Carra, Simon Alberti, Anthony A Hyman, Florian Stengel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
molecular condensates
RRM
chaperones
time-resolved quantitative XL-MS
FUS
aging
Online Access:https://elifesciences.org/articles/69377

Internet

https://elifesciences.org/articles/69377

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