Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory.

Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory.

Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function in adult hippocampal neurogenesis can cause learni...

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Bibliographic Details
Main Authors: Jacqueline A Bonds, Yafit Kuttner-Hirshler, Nancy Bartolotti, Matthew K Tobin, Michael Pizzi, Robert Marr, Orly Lazarov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4476567?pdf=render

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http://europepmc.org/articles/PMC4476567?pdf=render

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