A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins
Small G-proteins of the ADP-ribosylation-factor-like (Arl) subfamily have been shown to be crucial to ciliogenesis and cilia maintenance. Active Arl3 is involved in targeting and releasing lipidated cargo proteins from their carriers PDE6δ and UNC119a/b to the cilium. However, the guanine nucleotide...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-11-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/11859 |