CD169+ sinus macrophages in regional lymph nodes do not predict mismatch‐repair status of patients with colorectal cancer

CD169+ sinus macrophages in regional lymph nodes do not predict mismatch‐repair status of patients with colorectal cancer

Abstract Aims Mismatch‐repair deficiency and microsatellite instability‐high (dMMR/MSI‐H) colorectal cancer (CRC) is treated with programmed death (PD)‐1 antibody regardless of PD‐ligand (L)1 expression in tumor cells. We previously found that abundant CD169+ macrophages in regional lymph node (RLN)...

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Bibliographic Details
Main Authors: Yoichi Saito, Yukio Fujiwara, Yuji Miyamoto, Koji Ohnishi, Yuta Nakashima, Yasuhiko Tabata, Hideo Baba, Yoshihiro Komohara
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Cancer Medicine
Subjects:
CD169
colorectal cancer
dMMR/MSI‐H
PD‐L1
regional lymph node
sinus macrophage
Online Access:https://doi.org/10.1002/cam4.5747

Internet

https://doi.org/10.1002/cam4.5747

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