EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas.

EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas.

Latent membrane protein 1 (LMP1) is the major oncoprotein of Epstein-Barr virus (EBV). In transgenic mice, LMP1 promotes increased lymphoma development by 12 mo of age. This study reveals that lymphoma develops in B-1a lymphocytes, a population that is associated with transformation in older mice. T...

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Bibliographic Details
Main Authors: Kathy H Y Shair, Katherine M Bendt, Rachel H Edwards, Elisabeth C Bedford, Judith N Nielsen, Nancy Raab-Traub
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2065877?pdf=render

Internet

http://europepmc.org/articles/PMC2065877?pdf=render

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