Ultrasound-Targeted Microbubble Destruction Increases BBB Permeability and Promotes Stem Cell–Induced Regeneration of Stroke by Downregulating MMP8

The objective of this study was to evaluate the feasibility, safety, and effectiveness of intravenous stem cell delivery utilizing ultrasound-targeted microbubble destruction (UTMD) in a rat model of middle cerebral artery occlusion (MCAO), while investigating the underlying mechanisms. Acute cerebr...

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Bibliographic Details
Main Authors: Yun Bai, Yichao Du, Yin Yang, Thomas Wälchli, Paul E Constanthin, Fan Li
Format: Article
Language:English
Published: SAGE Publishing 2024-01-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/09636897231223293