MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

Summary: Emerging data suggest a significant cross-talk between metabolic and epigenetic programs. However, the relationship between the mechanistic target of rapamycin (mTOR), which is a pivotal metabolic regulator, and epigenetic modifications remains poorly understood. Our results show that mTORC...

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Bibliographic Details
Main Authors: HaEun Kim, Benjamin Lebeau, David Papadopoli, Predrag Jovanovic, Mariana Russo, Daina Avizonis, Masahiro Morita, Farzaneh Afzali, Josie Ursini-Siegel, Lynne-Marie Postovit, Michael Witcher, Ivan Topisirovic
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Molecular biology
Molecular mechanism of gene regulation
Epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224004097

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http://www.sciencedirect.com/science/article/pii/S2589004224004097

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