ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis

The ORM1 (Saccharomyces cerevisiae)-like proteins (ORMDLs) and their yeast orthologs, the Orms, are negative homeostatic regulators of the initiating enzyme in sphingolipid biosynthesis, serine palmitoyltransferase (SPT). Genome-wide association studies have established a strong correlation between...

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Bibliographic Details
Main Authors: Deanna Siow, Manjula Sunkara, Teresa M. Dunn, Andrew J. Morris, Binks Wattenberg
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Journal of Lipid Research
Subjects:
ceramides
enzymology/enzyme regulation
lung
sphingosine phosphate
endoplasmic reticulum
Orm
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752035570X

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http://www.sciencedirect.com/science/article/pii/S002222752035570X

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