Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins

Summary: Tetraspanins, a superfamily of membrane proteins, mediate diverse biological processes through tetraspanin-enriched microdomains in the plasma membrane. However, how their cell-surface presentation is controlled remains unclear. To identify the regulators of tetraspanin trafficking, we cond...

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Bibliographic Details
Main Authors: Jicheng Yang, Fusheng Guo, Hui San Chin, Gao Bin Chen, Chow Hiang Ang, Qingsong Lin, Wanjin Hong, Nai Yang Fu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000761

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http://www.sciencedirect.com/science/article/pii/S2211124723000761

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