The Compound <i>(E)</i>-2-Cyano-<i>N</i>,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases

The Compound <i>(E)</i>-2-Cyano-<i>N</i>,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases

The compound <i>(E)</i>-2-cyano-<i>N</i>,3-diphenylacrylamide (JMPR-01) was structurally developed using bioisosteric modifications of a hybrid prototype as formed from fragments of indomethacin and paracetamol. Initially, in vitro assays were performed to determine cell viab...

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Bibliographic Details
Main Authors: Pablo Rayff da Silva, Renan Fernandes do Espírito Santo, Camila de Oliveira Melo, Fábio Emanuel Pachú Cavalcante, Thássia Borges Costa, Yasmim Vilarim Barbosa, Yvnni M. S. de Medeiros e Silva, Natália Ferreira de Sousa, Cristiane Flora Villarreal, Ricardo Olímpio de Moura, Vanda Lucia dos Santos
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
bioisosterism
phenylacrylamide
immunomodulation
inflammation
Online Access:https://www.mdpi.com/1999-4923/14/1/188

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https://www.mdpi.com/1999-4923/14/1/188

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