Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model

Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model

Congenital cytomegalovirus (CMV) is a leading cause of disease in newborns and a vaccine is a high priority. The guinea pig is the only small animal model for congenital CMV but requires guinea pig cytomegalovirus (GPCMV). Previously, a disabled infectious single cycle (DISC) vaccine strategy demons...

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Bibliographic Details
Main Authors: K. Yeon Choi, Nadia S. El-Hamdi, Alistair McGregor
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
guinea pig
cytomegalovirus
glycoproteins
neutralizing antibody
congenital CMV
pentamer complex
Online Access:https://www.mdpi.com/1999-4915/14/4/760

Internet

https://www.mdpi.com/1999-4915/14/4/760

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