Assessment of Crosslinkers between Peptide Antigen and Carrier Protein for Fusion Peptide-Directed Vaccines against HIV-1

Assessment of Crosslinkers between Peptide Antigen and Carrier Protein for Fusion Peptide-Directed Vaccines against HIV-1

Conjugate-vaccine immunogens require three components: a carrier protein, an antigen, and a crosslinker, capable of coupling antigen to carrier protein, while preserving both T-cell responses from carrier protein and B-cell responses from antigen. We previously showed that the N-terminal eight resid...

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Bibliographic Details
Main Authors: Li Ou, Krishana Gulla, Andrea Biju, Daniel W. Biner, Tatsiana Bylund, Anita Changela, Steven J. Chen, Cheng-Yan Zheng, Nicole Cibelli, Angela R. Corrigan, Hongying Duan, Christopher A. Gonelli, Wing-Pui Kong, Cheng Cheng, Sijy O’Dell, Edward K. Sarfo, Andrew Shaddeau, Shuishu Wang, Alison Vinitsky, Yanhong Yang, Baoshan Zhang, Yaqiu Zhang, Richard A. Koup, Nicole A. Doria-Rose, Jason G. Gall, John R. Mascola, Peter D. Kwong
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Vaccines
Subjects:
conjugate vaccine
crosslinker
fusion peptide
HIV
Online Access:https://www.mdpi.com/2076-393X/10/11/1916

Internet

https://www.mdpi.com/2076-393X/10/11/1916

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