Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H<sub>2</sub>O<sub>2</sub> Together with Bicarbonate

Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H<sub>2</sub>O<sub>2</sub> Together with Bicarbonate

Protein tyrosine phosphatases (PTPs) can be regulated by several redox-dependent mechanisms and control growth factor-activated receptor tyrosine kinase phosphorylation cascades. Reversible oxidation of PTPs is counteracted by reductive enzymes, including thioredoxin (Trx) and Trx-related protein of...

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Bibliographic Details
Main Authors: Markus Dagnell, Qing Cheng, Elias S.J. Arnér
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
PTP1B
redox regulation
bicarbonate
peroxymonocarbonate
polysulfide
TrxR1
Online Access:https://www.mdpi.com/2076-3921/10/1/111

Internet

https://www.mdpi.com/2076-3921/10/1/111

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