Highly Efficient Darzens Reactions Mediated by Phosphazene Bases under Mild Conditions
Abstract The highly basic and poorly nucleophilic phosphazene base P1‐t‐Bu promotes the Darzens condensation of α‐halo esters with aromatic aldehydes affording α,β‐epoxy esters in nearly quantitative yields under mild conditions and in short reaction times. The more basic P4‐t‐Bu phosphazene was fou...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2022-10-01
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| Series: | ChemistryOpen |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/open.202200179 |