4078 Identification of distinct fibroblast populations with unique roles in pancreatic cancer progression and tumor immunity

OBJECTIVES/GOALS: The desmoplastic reaction in PDAC involves a significant accumulation of immune cells and fibroblasts.The functional diversity of carcinoma associated fibroblasts (CAFs) remains largely unknown, and identification of immune regulating subsets would have a substantial impact in augm...

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Bibliographic Details
Main Authors: Josephine Kebbeh Darpolor, Xiaofeng Zheng, Sujuan Yang, Hikaru Sugimoto, Julienne Carstens, Pedro Correa de Sampiao, Valerie LeBleu, Raghu Kalluri
Format: Article
Language:English
Published: Cambridge University Press 2020-06-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866120003015/type/journal_article