Conformational flexibility of apolipoprotein A-I amino- and carboxy-termini is necessary for lipid binding but not cholesterol efflux

Conformational flexibility of apolipoprotein A-I amino- and carboxy-termini is necessary for lipid binding but not cholesterol efflux

Because of its critical role in HDL formation, significant efforts have been devoted to studying apolipoprotein A-I (APOA1) structural transitions in response to lipid binding. To assess the requirements for the conformational freedom of its termini during HDL particle formation, we generated three...

Full description

Bibliographic Details
Main Authors: Shimpi Bedi, Jamie Morris, Amy Shah, Rachel C. Hart, W. Gray Jerome, Stephen G. Aller, Chongren Tang, Tomas Vaisar, Karin E. Bornfeldt, Jere P. Segrest, Jay W. Heinecke, W. Sean Davidson
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein A-I
ATP binding cassette transporter ABCA1
cholesterol efflux
electron microscopy
high-density lipoprotein
lecithin:cholesterol acyltransferase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000013

Internet

http://www.sciencedirect.com/science/article/pii/S0022227522000013

Similar Items