GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors.

GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors.

Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucle...

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Bibliographic Details
Main Authors: Atsuko Fukazawa, Carmen Alonso, Kiyotaka Kurachi, Sonal Gupta, Cammie F Lesser, Beth Ann McCormick, Hans-Christian Reinecker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2583055?pdf=render

Internet

http://europepmc.org/articles/PMC2583055?pdf=render

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