Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy

Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy

Chemotherapy has been used to inhibit cancer growth for decades, but emerging evidence shows it can affect the tumor stroma, unintentionally promoting cancer malignancy. After treatment of primary tumors, remaining drugs drain via lymphatics. Though all drugs interact with the lymphatics, we know li...

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Bibliographic Details
Main Authors: Alexandra R. Harris, Savieay Esparza, Mohammad S. Azimi, Robert Cornelison, Francesca N. Azar, Danielle C. Llaneza, Maura Belanger, Alexander Mathew, Svyatoslav Tkachenko, Matthew J. Perez, Claire Buchta Rosean, Raegan R. Bostic, R. Chase Cornelison, Kinsley M. Tate, Shayn M. Peirce-Cottler, Cherie Paquette, Anne Mills, Charles N. Landen, Jeff Saucerman, Patrick M. Dillon, Rebecca R. Pompano, Melanie A. Rutkowski, Jennifer M. Munson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
platinum
chemotherapy
lymphangiogenesis
metastasis
breast cancer
ovarian cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.801764/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.801764/full

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