Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin

Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin

Abstract Background The intratumor heterogeneity (ITH) of cancer cells plays an important role in breast cancer resistance and recurrence. To develop better therapeutic strategies, it is necessary to understand the molecular mechanisms underlying ITH and their functional significance. Patient-derive...

Full description

Bibliographic Details
Main Authors: Sumito Saeki, Kohei Kumegawa, Yoko Takahashi, Liying  Yang, Tomo Osako, Mahmut Yasen, Kazutaka Otsuji, Kenichi Miyata, Kaoru Yamakawa, Jun Suzuka, Yuri Sakimoto, Yukinori Ozaki, Toshimi Takano, Takeshi Sano, Tetsuo Noda, Shinji Ohno, Ryoji Yao, Takayuki Ueno, Reo Maruyama
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Breast Cancer Research
Subjects:
Intratumor heterogeneity
Breast cancer
Patient-derived organoids
scRNA-seq
Cancer cell diversity
Inflammatory breast cancer
Online Access:https://doi.org/10.1186/s13058-023-01617-4

Internet

https://doi.org/10.1186/s13058-023-01617-4

Similar Items