Identification of a conserved N‐terminal domain in the first module of ACV synthetases

Identification of a conserved N‐terminal domain in the first module of ACV synthetases

Abstract The l‐δ‐(α‐aminoadipoyl)‐l‐cysteinyl‐d‐valine synthetase (ACVS) is a trimodular nonribosomal peptide synthetase (NRPS) that provides the peptide precursor for the synthesis of β‐lactams. The enzyme has been extensively characterized in terms of tripeptide formation and substrate specificity...

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Bibliographic Details
Main Authors: Riccardo Iacovelli, László Mózsik, Roel A.L. Bovenberg, Arnold J.M. Driessen
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:MicrobiologyOpen
Subjects:
antibiotics
Nocardia lactamdurans
nonribosomal peptide synthetases
penicillin biosynthesis
Penicillium rubens
Online Access:https://doi.org/10.1002/mbo3.1145

Internet

https://doi.org/10.1002/mbo3.1145

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