Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens

Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens

Langerhans cells (LCs) are antigen-presenting cells that reside in the skin. They uniquely express high levels of the C-type lectin receptor Langerin (CD207), which is an attractive target for antigen delivery in immunotherapeutic vaccination strategies against cancer. We here assess a library of 20...

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Bibliographic Details
Main Authors: Rui-Jun Eveline Li, Tim P. Hogervorst, Silvia Achilli, Sven C. M. Bruijns, Sander Spiekstra, Corinne Vivès, Michel Thépaut, Dmitri V. Filippov, Gijs A. van der Marel, Sandra J. van Vliet, Franck Fieschi, Jeroen D. C. Codée, Yvette van Kooyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mannoside
tumor associated antigens
peptide conjugate
vaccine model
glyco-antigen
Langerhans cell
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00556/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00556/full

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