Targeting YAP1‐regulated Glycolysis in Fibroblast‐Like Synoviocytes Impairs Macrophage Infiltration to Ameliorate Diabetic Osteoarthritis Progression

Targeting YAP1‐regulated Glycolysis in Fibroblast‐Like Synoviocytes Impairs Macrophage Infiltration to Ameliorate Diabetic Osteoarthritis Progression

Abstract The interplay between immune cells/macrophages and fibroblast‐like synoviocytes (FLSs) plays a pivotal role in initiating synovitis; however, their involvement in metabolic disorders, including diabetic osteoarthritis (DOA), is largely unknown. In this study, single‐cell RNA sequencing (scR...

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Bibliographic Details
Main Authors: Jie Yang, Shanshan Li, Zhenyan Li, Lutian Yao, Meijing Liu, Kui‐Leung Tong, Qiutong Xu, Bo Yu, Rui Peng, Tao Gui, Wang Tang, Yidi Xu, Jiaxu Chen, Jun He, Kewei Zhao, Xiaogang Wang, Xiaoying Wang, Zhengang Zha, Huan‐Tian Zhang
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Advanced Science
Subjects:
diabetic osteoarthritis
fibroblast‐like synoviocytes
glycolysis
macrophages infiltration
YAP1
Online Access:https://doi.org/10.1002/advs.202304617

Internet

https://doi.org/10.1002/advs.202304617

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