Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review
Annulus fibrosus (AF) plays a crucial role in the biomechanical loading of intervertebral disc (IVD). AF is difficult to self-heal when the annulus tears develop, because AF has a unique intricate structure and biologic milieu in vivo. Tissue engineering is promising for repairing AF rupture, but co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-01-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23002517 |
| _version_ | 1797692807658340352 |
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| author | Dan Zhou Hongmei Liu Zhaomin Zheng Decheng Wu |
| author_facet | Dan Zhou Hongmei Liu Zhaomin Zheng Decheng Wu |
| author_sort | Dan Zhou |
| collection | DOAJ |
| description | Annulus fibrosus (AF) plays a crucial role in the biomechanical loading of intervertebral disc (IVD). AF is difficult to self-heal when the annulus tears develop, because AF has a unique intricate structure and biologic milieu in vivo. Tissue engineering is promising for repairing AF rupture, but construction of suitable mechanical matching devices or scaffolds is still a grand challenge. To deeply know the varied forces involved in the movement of the native annulus is highly beneficial for designing biomimetic scaffolds to recreate the AF function. In this review, we overview six freedom degrees of forces and adhesion strength on AF tissue. Then, we summarize the mechanical modalities to simulate related forces on AF and to assess the characteristics of biomaterials. We finally outline some current advanced techniques to develop mechanically adaptable biomaterials for AF rupture repair. |
| first_indexed | 2024-03-12T02:32:55Z |
| format | Article |
| id | doaj.art-85fc32414bd74fd49d33f647cbe2918a |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-03-12T02:32:55Z |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-85fc32414bd74fd49d33f647cbe2918a2023-09-05T04:16:10ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-01-0131422439Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A reviewDan Zhou0Hongmei Liu1Zhaomin Zheng2Decheng Wu3Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, ChinaGuangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China; Corresponding author.Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China; Pain Research Center, Sun Yat-Sen University, Guangzhou 510080, China; Corresponding author. Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China; Corresponding author.Annulus fibrosus (AF) plays a crucial role in the biomechanical loading of intervertebral disc (IVD). AF is difficult to self-heal when the annulus tears develop, because AF has a unique intricate structure and biologic milieu in vivo. Tissue engineering is promising for repairing AF rupture, but construction of suitable mechanical matching devices or scaffolds is still a grand challenge. To deeply know the varied forces involved in the movement of the native annulus is highly beneficial for designing biomimetic scaffolds to recreate the AF function. In this review, we overview six freedom degrees of forces and adhesion strength on AF tissue. Then, we summarize the mechanical modalities to simulate related forces on AF and to assess the characteristics of biomaterials. We finally outline some current advanced techniques to develop mechanically adaptable biomaterials for AF rupture repair.http://www.sciencedirect.com/science/article/pii/S2452199X23002517Annulus fibrosusForcesMechanical matchingHigh toughHigh adhesion |
| spellingShingle | Dan Zhou Hongmei Liu Zhaomin Zheng Decheng Wu Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review Bioactive Materials Annulus fibrosus Forces Mechanical matching High tough High adhesion |
| title | Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review |
| title_full | Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review |
| title_fullStr | Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review |
| title_full_unstemmed | Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review |
| title_short | Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review |
| title_sort | design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture a review |
| topic | Annulus fibrosus Forces Mechanical matching High tough High adhesion |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23002517 |
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