Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts

Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts

Heart failure is a leading cause of death and is often accompanied by activation of quiescent cardiac myofibroblasts, which results in cardiac fibrosis. In this study, we aimed to identify novel circular RNAs that regulate cardiac fibrosis. We applied transverse aortic constriction (TAC) for 1, 4, a...

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Bibliographic Details
Main Authors: Anna Jeong, Yongwoon Lim, Taewon Kook, Duk-Hwa Kwon, Young Kuk Cho, Juhee Ryu, Yun-Gyeong Lee, Sera Shin, Nakwon Choe, Yong Sook Kim, Hye Jung Cho, Jeong Chul Kim, Yoonjoo Choi, Su-Jin Lee, Hyung-Seok Kim, Hae Jin Kee, Kwang-Il Nam, Youngkeun Ahn, Myung Ho Jeong, Woo Jin Park, Young-Kook Kim, Hyun Kook
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Non-coding RNAs
circular RNA
transverse aortic constriction
cardiac fibrosis
circSMAD4
miR-671-5p
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002895

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http://www.sciencedirect.com/science/article/pii/S2162253123002895

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