Profilin 1 deficiency drives mitotic defects and reduces genome stability

Profilin 1 deficiency drives mitotic defects and reduces genome stability

A detailed characterization of in vitro and in vivo phenotypes of Pfn1 knockout cells demonstrates that loss of this gene results in cytoskeletal alterations, leading to mitotic defects and genome instability.

Bibliographic Details
Main Authors: Federica Scotto di Carlo, Sharon Russo, Francesc Muyas, Maria Mangini, Lorenza Garribba, Laura Pazzaglia, Rita Genesio, Flavia Biamonte, Anna Chiara De Luca, Stefano Santaguida, Katia Scotlandi, Isidro Cortés-Ciriano, Fernando Gianfrancesco
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04392-8

Internet

https://doi.org/10.1038/s42003-022-04392-8

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