The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC

The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC

The role of the gut microbiota in the occurrence and progression of primary biliary cholangitis (PBC) is not fully understood. First, the fecal microbiota of patients with PBC (n = 4) (PBC-FMT) or healthy individuals (n = 3) (HC-FMT) was transplanted into pseudo germ-free mice or 2OA-BSA–induced PBC...

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Bibliographic Details
Main Authors: Huiyong Jiang, Ying Yu, Xiaoxiang Hu, Bingbing Du, Yini Shao, Feiyu Wang, Lifeng Chen, Ren Yan, Lanjuan Li, Longxian Lv
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Gut Microbes
Subjects:
Primary biliary cholangitis
gut microbiota
fecal microbiota transplantation
metabolome
transcriptome
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2383353

Internet

https://www.tandfonline.com/doi/10.1080/19490976.2024.2383353

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