An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in <italic toggle="yes">Escherichia coli</italic>

ABSTRACT Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other. Despite their natural origin, discovering new natural products is challenging, and there is a...

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Bibliographic Details
Main Authors: Sara Cleto, Timothy K. Lu
Format: Article
Language:English
Published: American Society for Microbiology 2017-11-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mBio.01474-17