Insulin and α-Tocopherol Enhance the Protective Effect of Each Other on Brain Cortical Neurons under Oxidative Stress Conditions and in Rat Two-Vessel Forebrain Ischemia/Reperfusion Injury

Insulin and α-Tocopherol Enhance the Protective Effect of Each Other on Brain Cortical Neurons under Oxidative Stress Conditions and in Rat Two-Vessel Forebrain Ischemia/Reperfusion Injury

Clinical trials show that insulin administered intranasally is a promising drug to treat neurodegenerative diseases, but at high doses its use may result in cerebral insulin resistance. Identifying compounds which could enhance the protective effects of insulin, may be helpful to reduce its effectiv...

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Bibliographic Details
Main Authors: Irina O. Zakharova, Liubov V. Bayunova, Inna I. Zorina, Tatiana V. Sokolova, Alexander O. Shpakov, Natalia F. Avrova
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
insulin
α-tocopherol
protection
cortical neurons
oxidative stress
brain cortex
Online Access:https://www.mdpi.com/1422-0067/22/21/11768

Internet

https://www.mdpi.com/1422-0067/22/21/11768

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