Immune Modulating Brevetoxins: Monocyte Cytotoxicity, Apoptosis, and Activation of M1/M2 Response Elements Is Dependent on Reactive Groups

Immune Modulating Brevetoxins: Monocyte Cytotoxicity, Apoptosis, and Activation of M1/M2 Response Elements Is Dependent on Reactive Groups

Brevetoxins are a suite of marine neurotoxins that activate voltage-gated sodium channels (VGSCs) in cell membranes, with toxicity occurring from persistent activation of the channel at high doses. Lower doses, in contrast, have been shown to elicit neuroregeneration. Brevetoxins have thus been prop...

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Bibliographic Details
Main Authors: Jennifer R. McCall, Kathryn T. Sausman, Devon M. Keeler, Ariel P. Brown, Stephanie L. Turrise
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Marine Drugs
Subjects:
brevetoxin
inflammation
monocyte
T cell
cytotoxicity
apoptosis
Online Access:https://www.mdpi.com/1660-3397/20/4/233

Internet

https://www.mdpi.com/1660-3397/20/4/233

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