Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.

Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.

The active form of vitamin D3, 1,25(OH)2D3, has significant immunomodulatory properties and is an important determinant in the differentiation of CD4+ effector T cells. The biological actions of 1,25(OH)2D3 are mediated by the vitamin D receptor (VDR) and are believed to correlate with the VDR prote...

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Bibliographic Details
Main Authors: Martin Kongsbak, Marina R von Essen, Lasse Boding, Trine B Levring, Peter Schjerling, Jens P H Lauritsen, Anders Woetmann, Niels Ødum, Charlotte M Bonefeld, Carsten Geisler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096695&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096695&type=printable

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