Quercetin confers protection of murine sepsis by inducing macrophage M2 polarization via the TRPM2 dependent calcium influx and AMPK/ATF3 activation

Quercetin confers protection of murine sepsis by inducing macrophage M2 polarization via the TRPM2 dependent calcium influx and AMPK/ATF3 activation

M2 macrophage polarization plays a crucial role in counteracting inflammatory disorders such as sepsis. Quercetin is a dietary flavonoid that possesses robust anti-inflammatory properties. However, it is not known whether quercetin takes effects by directly promoting M2 polarization in macrophages....

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Bibliographic Details
Main Authors: Yuanfeng Zhu, Shijun Fan, Yongling Lu, Yan Wei, Ju Tang, Yongjun Yang, Fangfang Li, Qian Chen, Jiang Zheng, Xin Liu
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Journal of Functional Foods
Subjects:
Quercetin
Sepsis
Macrophage polarization
TRPM2
AMPK
ATF3
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464619301203

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http://www.sciencedirect.com/science/article/pii/S1756464619301203

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