MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

Methyl-CpG-binding protein 2 (MECP2) is a critical transcriptional regulator for synaptic function. Dysfunction of synapses, as well as microglia-mediated neuroinflammation, represent the earliest pathological events in Alzheimer’s disease (AD). Here, expression, protein levels, and activity-related...

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Bibliographic Details
Main Authors: Rebekka Wittrahm, Mari Takalo, Mikael Marttinen, Teemu Kuulasmaa, Petra Mäkinen, Susanna Kemppainen, Henna Martiskainen, Tuomas Rauramaa, Ian Pike, Ville Leinonen, Teemu Natunen, Annakaisa Haapasalo, Mikko Hiltunen
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
Alzheimer’s disease
MECP2
microglia
neuroinflammation
post-translational modifications
synaptic markers
Online Access:https://www.mdpi.com/2073-4409/10/4/860

Internet

https://www.mdpi.com/2073-4409/10/4/860

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