Homozygous CRISPR/Cas9 Knockout Generated a Novel Functionally Active Exon 1 Skipping XPA Variant in Melanoma Cells

Homozygous CRISPR/Cas9 Knockout Generated a Novel Functionally Active Exon 1 Skipping XPA Variant in Melanoma Cells

Defects in DNA repair pathways have been associated with an improved response to immune checkpoint inhibition (ICI). In particular, patients with the nucleotide excision repair (NER) defect disease Xeroderma pigmentosum (XP) responded impressively well to ICI treatment. Recently, in melanoma patient...

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Bibliographic Details
Main Authors: Veronika Banicka, Marie Christine Martens, Rüdiger Panzer, David Schrama, Steffen Emmert, Lars Boeckmann, Alexander Thiem
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
DNA repair
nucleotide excision repair
XPA
CRISPR
knockout
protein variant
Online Access:https://www.mdpi.com/1422-0067/23/19/11649

Internet

https://www.mdpi.com/1422-0067/23/19/11649

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