Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti
Abstract Mammalian sensory hair cells (HCs) have limited capacity for regeneration, which leads to permanent hearing loss after HC death. Here, we used in vitro RNA-sequencing to show that the Hippo signaling pathway is involved in HC damage and self-repair processes. Turning off Hippo signaling thr...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-10-01
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Series: | npj Regenerative Medicine |
Online Access: | https://doi.org/10.1038/s41536-022-00261-4 |