Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti

Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti

Abstract Mammalian sensory hair cells (HCs) have limited capacity for regeneration, which leads to permanent hearing loss after HC death. Here, we used in vitro RNA-sequencing to show that the Hippo signaling pathway is involved in HC damage and self-repair processes. Turning off Hippo signaling thr...

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Bibliographic Details
Main Authors: Xiaoling Lu, Huiqian Yu, Jiaoyao Ma, Kunkun Wang, Luo Guo, Yanping Zhang, Boan Li, Zehang Zhao, Huawei Li, Shan Sun
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-022-00261-4

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