Pharmacological Evidence That <i>Dictyostelium</i> Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in Mouse 3T3-L1 Cells

Pharmacological Evidence That <i>Dictyostelium</i> Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in Mouse 3T3-L1 Cells

Differentiation-inducing factor 1 (DIF-1) isolated from the cellular slime mold <i>Dictyostelium discoideum</i> can inhibit mammalian calmodulin-dependent cAMP/cGMP phosphodiesterase (PDE1) in vitro. DIF-1 also promotes glucose uptake, at least in part, via a mitochondria- and AMPK-depen...

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Bibliographic Details
Main Authors: Yuzuru Kubohara, Yuko Fukunaga, Haruhisa Kikuchi, Hidekazu Kuwayama
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
<i>Dictyostelium discoideum</i>
DIF-1
obesity
diabetes
PDE1
cAMP
Online Access:https://www.mdpi.com/1420-3049/28/23/7926

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https://www.mdpi.com/1420-3049/28/23/7926

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