Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review
ABSTRACT BACKGROUND: Rheumatic diseases (RDs) are a group of pathological conditions characterized by inflammation and functional disability. There is evidence suggesting that regular consumption of polyphenols has therapeutic effects capable of relieving RD symptoms. OBJECTIVE: To synthesize data...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2021-11-01
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000600615&tlng=en |
| _version_ | 1828131918413037568 |
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| author | Hillary Nascimento Coletro Amanda Popolino Diniz Nathália Sernizon Guimarães Júlia Cristina Cardoso Carraro Raquel de Deus Mendonça Adriana Lúcia Meireles |
| author_facet | Hillary Nascimento Coletro Amanda Popolino Diniz Nathália Sernizon Guimarães Júlia Cristina Cardoso Carraro Raquel de Deus Mendonça Adriana Lúcia Meireles |
| author_sort | Hillary Nascimento Coletro |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Rheumatic diseases (RDs) are a group of pathological conditions characterized by inflammation and functional disability. There is evidence suggesting that regular consumption of polyphenols has therapeutic effects capable of relieving RD symptoms. OBJECTIVE: To synthesize data from randomized controlled trials on administration of polyphenols and their effects on RD activity. DESIGN AND SETTING: Systematic review conducted at Universidade Federal de Ouro Preto, Minas Gerais, Brazil. METHODS: A systematic search was conducted in the databases PubMed (Medline), LILACS (BVS), IBECS (BVS), CUMED (BVS), BINACIS (BVS), EMBASE, Web of Science and Cochrane Library and in the grey literature. The present study followed a PRISMA-P checklist. RESULTS: In total, 646 articles were considered potentially eligible, of which 33 were then subjected to complete reading. Out of these, 17 randomized controlled trials articles were selected to form the final sample. Among these 17 articles, 64.71% assessed osteoarthritis (n = 11), 23.53% rheumatoid arthritis (n = 4), 5.88% rheumatoid arthritis and fibromyalgia (n = 1) and 5.88% osteoarthritis and rheumatoid (n = 1). Intake of polyphenol showed positive effects in most of the studies assessed (94.12%): it improved pain (64.70%) and inflammation (58.82%). CONCLUSION: Polyphenols are potential allies for treating RD activity. However, the range of polyphenol sources administered was a limitation of this review, as also was the lack of information about the methodological characteristics of the studies evaluated. Thus, further primary studies are needed in order to evaluate the effects of polyphenol consumption for reducing RD activity. SYSTEMATIC REVIEW REGISTER: PROSPERO - CRD42020145349. |
| first_indexed | 2024-04-11T16:55:35Z |
| format | Article |
| id | doaj.art-86255d651e314366aa43f0aa382fe8fd |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-04-11T16:55:35Z |
| publishDate | 2021-11-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-86255d651e314366aa43f0aa382fe8fd2022-12-22T04:13:16ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602021-11-01139661562310.1590/1516-3180.2020.0766.r1.22042021Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic reviewHillary Nascimento Coletrohttps://orcid.org/0000-0002-9142-6079Amanda Popolino Dinizhttps://orcid.org/0000-0002-3300-0440Nathália Sernizon Guimarãeshttps://orcid.org/0000-0002-0487-0500Júlia Cristina Cardoso Carrarohttps://orcid.org/0000-0003-0027-2690Raquel de Deus Mendonçahttps://orcid.org/0000-0001-7599-8715Adriana Lúcia Meireleshttps://orcid.org/0000-0002-1447-953XABSTRACT BACKGROUND: Rheumatic diseases (RDs) are a group of pathological conditions characterized by inflammation and functional disability. There is evidence suggesting that regular consumption of polyphenols has therapeutic effects capable of relieving RD symptoms. OBJECTIVE: To synthesize data from randomized controlled trials on administration of polyphenols and their effects on RD activity. DESIGN AND SETTING: Systematic review conducted at Universidade Federal de Ouro Preto, Minas Gerais, Brazil. METHODS: A systematic search was conducted in the databases PubMed (Medline), LILACS (BVS), IBECS (BVS), CUMED (BVS), BINACIS (BVS), EMBASE, Web of Science and Cochrane Library and in the grey literature. The present study followed a PRISMA-P checklist. RESULTS: In total, 646 articles were considered potentially eligible, of which 33 were then subjected to complete reading. Out of these, 17 randomized controlled trials articles were selected to form the final sample. Among these 17 articles, 64.71% assessed osteoarthritis (n = 11), 23.53% rheumatoid arthritis (n = 4), 5.88% rheumatoid arthritis and fibromyalgia (n = 1) and 5.88% osteoarthritis and rheumatoid (n = 1). Intake of polyphenol showed positive effects in most of the studies assessed (94.12%): it improved pain (64.70%) and inflammation (58.82%). CONCLUSION: Polyphenols are potential allies for treating RD activity. However, the range of polyphenol sources administered was a limitation of this review, as also was the lack of information about the methodological characteristics of the studies evaluated. Thus, further primary studies are needed in order to evaluate the effects of polyphenol consumption for reducing RD activity. SYSTEMATIC REVIEW REGISTER: PROSPERO - CRD42020145349.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000600615&tlng=enAntioxidantsRheumatic diseasesPolyphenolsRheumatoid arthritisOsteoarthritisPhenolic compoundsNutritionEpidemiologyHuman health |
| spellingShingle | Hillary Nascimento Coletro Amanda Popolino Diniz Nathália Sernizon Guimarães Júlia Cristina Cardoso Carraro Raquel de Deus Mendonça Adriana Lúcia Meireles Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review São Paulo Medical Journal Antioxidants Rheumatic diseases Polyphenols Rheumatoid arthritis Osteoarthritis Phenolic compounds Nutrition Epidemiology Human health |
| title | Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review |
| title_full | Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review |
| title_fullStr | Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review |
| title_full_unstemmed | Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review |
| title_short | Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review |
| title_sort | polyphenols for improvement of inflammation and symptoms in rheumatic diseases systematic review |
| topic | Antioxidants Rheumatic diseases Polyphenols Rheumatoid arthritis Osteoarthritis Phenolic compounds Nutrition Epidemiology Human health |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000600615&tlng=en |
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